Object
To clarify involvement of mast cells in pathological process of scleroderma.
Methods
Histology:
Skin biopsy was performed for diagnostic purposes;
- ・Scleroderma (systemic sclerosis; SSc):54 cases
- ・Non-SSc (Collagen disease): 29 cases
- ・Control:10 cases- Autopsy, Healthy skin histology in median section
Increased mast cells in the dermis of a SSc patient
Increased mast cells in the dermis of SSc patients
The association of the number of dermis mast cells with the severity of skin sclerosis
The association of the number of dermis mast cells with the severity of PAH
Increased dermis mast cells of SSc patients with PAH
Increase pulmonary interstitium mast cells co-localizing with pulmonary artery in SSc-PAH
SSc-PAH (one case) lung tissue findings with intimal thickening with increase of elastic fiber / collagen fiber
TGF-b and PDGF production from dermis mast cell in SSc
TGF-b and PDGF production by mast cells in pulmonary interstitium of SSc-PAH
